Michelle Spruill, PhD, M.Sc., MT (Chem)

Chief Quality Officer and Vice-President of Laboratory Operations
Michelle Spruill, M.Sc. MT

Michelle Spruill, PhD, M.Sc., MT (Chem), is a highly accomplished professional in the field of toxicology with a rich history of expertise in various aspects of the discipline. With a Master of Science in Biology, a PhD in Pharmaceutics, and extensive experience in laboratory management and method development, Dr. Spruill has consistently demonstrated her dedication to advancing the field of toxicology and the pharmaceutical sciences.

Throughout her career, she has showcased her proficiency with a wide range of cutting-edge instrumentation, including enzyme immunoassay screening on a Beckman Coulter AU400 and AU 480, liquid chromatography-tandem mass spectrometry on ABSciex, Shimadzu, Waters, and mass spectrometry imaging on a MALDI-TOF Bruker Ultraflex. In addition, Dr. Spruill’s compliance experience is particularly noteworthy, as she, in conjunction with Howard “Trey” Martin, MD, has successfully converted a laboratory from imminent jeopardy status to a state of zero deficiencies in CMS region 6. This experience highlights her commitment to laboratory compliance, quality, and safety.

As Chief Quality Officer and VP of Laboratory Operations at Sagis, Michelle remains pivotal in method development and process improvements in the toxicology department, demonstrating her leadership and project coordination skills. Her ability to design and conduct establishment and stability studies for biological specimens has contributed significantly to the development and validation of analytical methods at Sagis.

In tandem with her professional accomplishments, Dr. Spruill continues to showcase her dedication to ongoing research and innovation. Her poster presentations and publications in respected scientific journals underline her commitment to advancing knowledge in the field of toxicology and the pharmaceutical sciences.

With her extensive knowledge, technical expertise, and dedication to excellence, Michelle Spruill is a recognized leader in toxicology. She has made significant contributions to the field and inspired future generations of researchers.



University of Texas
Odessa, TX

Graduate School

Ph.D., Pharmaceutics
University of Houston
Houston, TX

M.Sc., Biology, Genetics
University of Texas of the Permian Basin
Odessa, TX

Board Certifications

Medical Technologist

ABOR AAB Board of Registry in Chemistry

Clinical Laboratory Scientist— Chemistry

Louisiana State Board of Medical Examiners


American Society for Mass Spectrometry (ASMS)

Research & Publications

Research & Publications
  • Spruill ML, Maletic-Savatic M, Martin H, Li F, Liu X. Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging. Biochem Pharmacol. 2022 Jul;201:115080. doi: 10.1016/j.bcp.2022.115080. Epub. 2022 May 10. PMID: 35561842.
  • Co-Author, Comparison of purified β-glucuronidases in patient urine samples indicate a lack of correlation between enzyme activity and drugs of abuse metabolites hydrolysis efficiencies leading to potential false negatives, Journal of Analytical Toxicology, 2018.
Poster Presentations
  • Poster Presentation at Society of Forensic Toxicologists (SOFT, 2018): Co-Author, The Importance of pH in β-Glucuronidase Hydrolysis Efficiency
  • Poster Presentation at American Society for Mass Spectrometry (ASMS, 2020): Simultaneous quantitation of dexamethasone and dexamethasone phosphate in mice whole blood and tissue by triple quadrupole LC-MS/MS using isotope dilution method.
  • Poster Presentation at American Society for Mass Spectrometry (ASMS, 2023): Analysis and simultaneous quantitation of isoform-specific phosphoinositide 3-kinase (PI3K) inhibitors in mice plasma by LC-MS/MS and its application to pharmacokinetics.