[December 5, 2024]— In a November 2024 Melanoma Research Alliance article, George Mannes, an established editor and longtime writer living in New York, shared his story with the world. In doing so, he hopes to make more people aware of the rare condition known as acral melanoma. During George’s journey to diagnosis and treatment, providence led him to meet Bryan C. Markinson, DPM, one of Sagis’ distinguished and experienced Podiatric Clinical Affairs Board Co-Chairs and Sr. Vice President of Podiatric Education.
The Diagnostic Journey: George’s Melanoma Story
For George, an avid runner, his journey began with what appeared to be a common issue—a discolored toenail following an injury. Initially dismissed during a routine skin check, it wasn’t until years later, when a blood blister appeared. With that, George’s PCP referred him to Dr. Bryan Markinson at the Icahn School of Medicine at Mount Sinai. Dr. Markinson immediately recognized the possible signs of acral melanoma and performed a biopsy, confirming the diagnosis within a week.
“I had no idea this type of melanoma existed,” George shared. “I thought melanoma was linked to sun exposure. My case didn’t even have the classic ‘racing stripe’ associated with acral melanoma.”
Dr. Markinson’s expertise highlights the importance of specialist involvement in recognizing rare conditions that might likely go unnoticed.
More About Acral Melanoma
Acral melanoma is a rare and aggressive melanoma subtype. It forms on the palms, soles, or under nails, and is also unrelated to sun exposure. Additionally, this condition accounts for only 1-3% of melanoma cases. It also disproportionately affects individuals with darker skin tones, including African Americans, Asians, and Hispanics. This rarity and subtle presentation underscore the critical role of specialized diagnostic processes and proactive awareness campaigns.
Navigating Treatment Challenges
Following his diagnosis, George’s treatment began with the amputation of his affected toe and a sentinel lymph node biopsy, revealing that the cancer had spread. Under the care of experts at Memorial Sloan Kettering Cancer Center, George underwent a series of treatments, including immunotherapy, chemotherapy with imatinib, and viral therapy using Imlygic® injections.
Despite setbacks, Mr. Mannes’ resilience and access to advanced medical care underscore the importance of comprehensive treatment plans tailored to individual needs.
Raising Awareness and Driving Change
Dr. Markinson’s efforts extend beyond individual diagnoses. His “More Eyes on Melanoma” campaign educates nail technicians—who are uniquely positioned to notice early signs of acral melanoma—on identifying potential warning signs. George’s experience also highlights the need for broader awareness among healthcare providers and patients.
Although no definitive link exists between trauma and acral melanoma, studies suggest a potential association, emphasizing the need for continued research. George has contributed to the Melanoma Research Alliance’s RARE Registry, sharing his journey to advance the understanding and treatment of acral melanoma and other rare subtypes.
The Role of Pathology in Diagnosis
Pathology plays a vital role in diagnosing conditions like acral melanoma. Through expert analysis, pathologists provide accurate diagnoses that inform life-saving treatment strategies. Sagis Diagnostics is committed to supporting specialists like Dr. Markinson in improving diagnostic precision and advancing patient care.
By spotlighting acral melanoma, Sagis Diagnostics underscores the importance of early detection, collaboration among medical professionals, and ongoing education to ensure better outcomes for patients facing this challenging disease.
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